Name: DANIEL ANDRES GOMEZ SAIZ
Publication date: 18/11/2025
Examining board:
Name |
Role |
|---|---|
| ANDRE SOARES LEOPOLDO | Presidente |
| DANILO SALES BOCALINI | Examinador Interno |
| DIJON HENRIQUE SALOMÉ DE CAMPOS | Examinador Externo |
Summary: Obesity is an important public health problem and is associated with metabolic, infl
ammatory and structural changes that compromise the cardiovascular system. In
this context, capsinoids, non-pungent compounds analogous to capsaicin, and
continuous aerobic exercise emerge as promising strategies to mitigate the
deleterious effects of obesity on the cardiac remodeling process. The present study
aimed to investigate the effects of chronic administration of capsinoids and
continuous aerobic exercise on the cardiac morphology of rats with diet-induced
obesity. Male Wistar rats were fed a standard or high-fat diet for 27 consecutive
weeks. The experimental protocol was divided into two moments: M1) induction and
maintenance of obesity (19 weeks) and M2) chronic exposure to capsinoids and the
continuous aerobic exercise training protocol (8 weeks). Subsequently, the obese
(Ob) animals were distributed into four experimental groups: Ob; Obese
supplemented with capsinoids (ObCap); Obese subjected to continuous aerobic
exercise training (ObTr); an obese subject supplemented with capsaicinoids and
subjected to continuous aerobic physical training (ObCapTr). Food parameters,
metabolic and hormonal profiles, physical performance, and cardiorespiratory
fitness, as well as indicators of cardiac remodeling and damage, were evaluated.
The results showed that the high-fat diet induced obesity, increased adiposity, and
changes in the glycemic profile, such as glucose intolerance. Treatment with
capsnoids and physical exercise was not able to reduce adiposity or promote
improvements in glycemic and lipid profiles. However, an improvement in
cardiorespiratory performance and a reduction in cardiac damage were observed.
In conclusion, chronic administration of capsnoids combined with continuous
aerobic physical exercise did not exert beneficial effects on adiposity and cardiac
morphology, but significantly improved cardiorespiratory fitness and reduced
cardiac damage in obesity induced by high-fat diet.
