Name: DANIELE CRISTINA DE OLIVEIRA
Publication date: 25/10/2024
Examining board:
Name |
Role |
|---|---|
| CARMEM LUIZA SARTÓRIO | Examinador Externo |
| FERNANDO ZANELA DA SILVA AREAS | Examinador Interno |
Summary: Mental disorders, such as depression and anxiety, have been considered the
most disabling diseases in recent decades, according to PAHO/WHO. Affecting
individuals across all age groups, without distinction of race, creed, and/or other
inherent human characteristics, this issue constitutes a serious public health problem,
as it directly impacts the global burden of disease. It also surpasses individual
suffering, affecting families, communities, and entire economies due to loss of
individual productivity and increased use of healthcare services. The lack of adequate
treatment or early intervention further increases the economic burden. However,
despite advancements in the approach to the disease and pharmacological treatment,
adherence is considered low and inefficient. Based on this, the present study tested
the hypothesis of the neuroprotective effect of the phytotherapeutic Rosmarinic Acid
(RA), present in various plants and easily accessible to patients, as well as offering
lower costs and fewer undesirable side effects.
The effects of RA were analyzed at concentrations of 100mg and 20mg, along
with the use of a positive control for validation purposes in Swiss mice. In the groups
treated with RA, it was not possible to find a significant difference that would
corroborate current literature. In fact, a reverse effect was observed with the
administration of RA at 100mg. However, in the positive control group with fluoxetine,
an increase in biogenic amines was evidenced in the amygdala, which are involved in
the process of the disorders studied, along with its anxiolytic effect in the elevated plus
maze test, thus validating the behavioral experiment but not the corresponding
phytotherapeutic – RA. Therefore, it is concluded that administration of the bioactive
compound in the chosen lineage did not demonstrate the expected effect, which could
be related to both the lineage and the bioactive’s form. Given this, further studies are
necessary to assess the effects of RA described in the literature.
